Eloralintide

Product Name: Eloralintide

Chemical Information:

• CAS Number: 2883634-40-8
• Molecular Formula: C₂₀₁H₃₁₉N₄₉O₆₅S₂
• Molecular Weight: ~4526.1 g/mol (approximate; refer to Certificate of Analysis for exact value)
• Sequence: {γGlu}-CNTATCATG-{Orn}-LAE-{α-Me-Phe}-LVRSSN-{N-Me-Asn}-FGP-{Lys(γGlu-γGlu-C20 diacid)}-LPPTEVGSNTY-NH₂ (methylene thioacetal bridge: Cys²–Cys⁷)
• Peptide Length: 37 amino acids
• Compound Class: Synthetic lipidated peptide analogue (amylin-derived)

Product Description: Eloralintide is a synthetic 37-residue peptide analogue structurally derived from amylin, featuring several defined modifications to the parent sequence. The native Cys²–Cys⁷ disulfide bond is replaced with a methylene thioacetal bridge, three non-coded amino acids are incorporated (ornithine, α-methyl-phenylalanine, and N-methyl-asparagine), and a fatty diacid side chain is conjugated at the lysine residue in position 26. The C-terminus is amidated. These modifications make the compound a useful reference material for laboratory investigation of peptide stability, aggregation behavior, and the analytical characterization of lipidated peptides. This product is supplied as a lyophilized powder, intended exclusively for in vitro laboratory research by qualified professionals.

Nomenclature Note: This compound appears in the published scientific literature under the nonproprietary name eloralintide. The development code LY3841136 is used by a third-party clinical developer and is referenced here solely for literature cross-identification purposes. No affiliation, sponsorship, or endorsement is claimed or implied.

Research Applications:

• Receptor interaction characterization in defined in vitro assay systems
• Comparative stability analysis of thioacetal-bridged versus disulfide-bridged peptide structures
• Evaluation of aggregation and fibrillation propensity relative to unmodified amylin sequences under controlled conditions
• Chromatographic and mass spectrometric method development for lipidated peptides
• Structure–property relationship analysis of non-coded amino acid substitutions

Storage and Handling:

• Store the lyophilized powder at −20 °C
• Once reconstituted, store at 2–8 °C and use promptly
• Protect from light
• Maintain aseptic handling practices to ensure product quality and sterility

Product Specifications:

• Purity: ≥99% (HPLC Certified)
• Identity: Confirmed by LC-MS against theoretical molecular weight (refer to Certificate of Analysis)
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in suitable laboratory agents

Compliance Notice:

Eloralintide is FOR RESEARCH USE ONLY as an analytical reference material. This compound corresponds structurally to an investigational substance currently under clinical development by a third-party pharmaceutical developer. It has not been approved by the FDA for any use. This research material is not the investigational product, is not manufactured under GMP conditions, is not equivalent to or a substitute for any investigational or approved pharmaceutical product, and is not intended for human or veterinary use. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.