Manufacturing

OUR PEPTIDES

Where they cOme frOm. HOw they're maDe.

There are two ways peptides are produced: chemical synthesis or biological production. Chemical synthesis builds the peptide one amino acid at a time from defined starting materials. Biological production uses living organisms — typically bacteria or yeast — engineered to express the peptide.

All of our peptides are produced by independent third-party laboratories using solid-phase peptide synthesis. Nearly all SPPS facilities are based outside the US — that’s the global reality of how this raw material is made.

Those raw materials are then lyophilized into the powder form you receive in the vial. This last step happens in so called ‘finishing’ labs around the world, including in the US — and over the last 5–6 months, that’s where Pure Health Peptides has moved to.

That’s where (y)our product comes from. That’s why we test it the way we do — so you can be sure that what you receive is fully verified.

More tests on a COA do not necessarily mean better testing. The relevant question is whether the tests reported are the ones t hat verify quality for the manufacturing method that produced the material.

— Nisrin Samsum 
CEO, Ethos Analytics

What Our manufacturing methOD means fOr testing

A pattern is emerging in the research peptide market: suppliers competing on the number of tests on a COA rather than whether those tests are the right ones for the material being analyzed. The relevant question isn’t how many tests appear — it’s whether they actually verify quality for the manufacturing method and supply chain that produced the product. 

For chemically synthesized peptides, three tests address the peptide itself: identity (mass spectrometry), purity (HPLC/UHPLC), and quantity. These confirm the synthesis produced the correct compound, at the correct purity, in the correct amount.  

Two further tests address the supply chain rather than the chemistry. Even when production involves no bacteria, handling, lyophilization, vial filling, storage, and transit are real contamination routes. Endotoxin testing (USP <85>) and microbial limits testing (USP <61>/<62>) confirm those downstream routes stayed clean. 

Other tests have narrow applicability here. Heavy metals and residual solvents are addressed at the source — through reagent quality control and validated lyophilization — rather than batch-level testing.  

Our standard panel reports the five measurements that are genuinely diagnostic for chemically synthesized lyophilized peptides in our supply chain: identity, purity, quantity, endotoxin, and microbial limits. We don’t pad the panel with tests of narrow applicability for our method — that’s analytical theater, not analytical rigor.